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Portuguese scientists have shown that the death of nerve cells in Alzheimer's disease is partly a defensive reaction of the organism to the growing number of malfunctioning neurons. This mechanism allows the brain to deal with aging, prolonging its normal operation.
Press release with the results of the work available on EurekAlert!, the news of it with reference to lenta.ru.
the Researchers studied genetically modified flies, which are an animal model of Alzheimer's disease. In the cells of the brain produces proteins beta-amyloid which is believed to play a key role in the development of neurodegenerative diseases.
the human brain, beta-amyloid form plaques, causing cell death. The flies experience symptoms similar to signs of dementia in humans, including loss of long term memory, problems with coordination of movement and accelerated aging of the nervous tissue.
the Researchers tested if neurons are dying by themselves or death due to the presence beside them healthier cells, which are beginning to compete successfully. In the latter case, there is a "quality control" cells, which can survive more resistant neurons. Destruction of bad cells is a natural way of self-renewal of the organism, which delays the aging process. Then, like the death of cells can counteract the progression of dementia.
it Turned out that, if you block the death of neurons, insects quickly develop symptoms of Alzheimer's disease, and the flies died sooner. On the contrary, the acceleration mechanism of "quality control" led to the recovery of cognitive functions of the brain including memory and learning. According to the researchers, the results will help to develop new therapies for neurodegenerative diseases, however, need to prove that they are effective in humans.
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